VAT Trap Blog

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GLP-1 therapies reduce cardiovascular events, likely through visceral adipose tissue reduction, reframing cardiology treatment toward upstream metabolic disease targeting

If the pharmacological effects of GLP-1 drugs disappear within weeks, why does the weight rebound take years? And how can that gap be used as a permanent metabolic reset? Written by Dr Edward Leatham, Consultant Cardiologist© 2026 E. Leatham VAT-TRAP Series Key Clinical Findings 1 1 Weight regain is slow despite rapid drug clearance. GLP-1 pharmacological effects fade within weeks, yet full weight rebound takes an average of 1.7 years — because body weight is biologically de