VAT Trap Blog

If the pharmacological effects of GLP-1 drugs disappear within weeks, why does the weight rebound take years? And how can that gap be used as a permanent metabolic reset? Written by Dr Edward Leatham, Consultant Cardiologist © 2026 E. Leatham VAT-TRAP Series Key Clinical Findings 1 1 Weight regain is slow despite rapid drug clearance. GLP-1 pharmacological effects fade within weeks, yet full weight rebound takes an average of 1.7 years — because body weight is biologically d