VAT Trap Blog

Appetite suppression is the dominant, well-evidenced mechanism behind GLP-1 and dual GIP/GLP-1 drugs. It is probably most of the story — but a patient losing a stone in six weeks on a sub-licensed dose, with almost no dietary change, sits in the part it does not comfortably explain. The grown-up response to that gap is not to pretend, but to ask better questions. This series asks one of them.

Cardiovascular deaths fell 70–80% in sixty years — one of medicine's greatest triumphs. But progress is now slowing. Visceral fat, not LDL-C, is the upstream driver of the four real epidemic diseases: atrial fibrillation, heart failure, type 2 diabetes, and dementia. The VAT-TRAP four-pillar framework addresses all four simultaneously.